abstract：BACKGROUND:New tests, such as magnetic resonance imaging (MRI) and electron-beam computed tomography (CT), are being developed for the diagnosis of coronary artery disease. OBJECTIVE:To determine the conditions that a new test must meet to be a cost-effective alternative to established imaging tests. DESIGN:Decision ...

journal_title：Annals of internal medicine

authors： Hunink MG,Kuntz KM,Fleischmann KE,Brady TJ

更新日期：1999-11-02 00:00:00

abstract：BACKGROUND:Recently, liver transplantation has been used to treat patients with familial amyloid polyneuropathy (FAP). OBJECTIVE:To describe the clinical course of patients with FAP who received partial-liver transplantation from living donors. DESIGN:Case series. SETTING:University hospital in Matsumoto, Japan. PA...

journal_title：Annals of internal medicine

authors： Takei Y,Ikeda S,Hashikura Y,Ikegami T,Kawasaki S

更新日期：1999-10-19 00:00:00

abstract：BACKGROUND:The frequency and severity of post-thrombotic sequelae after spontaneous axillary-subclavian venous thrombosis remain poorly known. OBJECTIVE:To determine the late sequelae of conventionally treated spontaneous axillary-subclavian venous thrombosis. DESIGN:Cross-sectional study. SETTING:University departm...

journal_title：Annals of internal medicine

authors： Héron E,Lozinguez O,Emmerich J,Laurian C,Fiessinger JN

更新日期：1999-10-05 00:00:00

abstract：BACKGROUND:Preventive therapy is an important element of syphilis control efforts. No currently recommended, single-dose alternatives to penicillin G benzathine are available for treatment of incubating syphilis. OBJECTIVE:To evaluate the use of a single 1.0-g dose of azithromycin for treatment of persons recently exp...

journal_title：Annals of internal medicine

authors： Hook EW 3rd,Stephens J,Ennis DM

更新日期：1999-09-21 00:00:00

abstract：PURPOSE:To review epidemiologic studies on the association between homocyst(e)ine level and risk for cardiovascular disease and the potential benefits of homocysteine-decreasing therapies. DATA SOURCES:Computerized and manual searches of the literature on total homocysteine levels and cardiovascular disease. STUDY SE...

journal_title：Annals of internal medicine

authors： Eikelboom JW,Lonn E,Genest J Jr,Hankey G,Yusuf S

更新日期：1999-09-07 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence of hyperinsulinemia is the primary cause of fasting hyperglycemia; after a meal, impaired suppression of hepatic glucose ...

journal_title：Annals of internal medicine

authors： DeFronzo RA

更新日期：1999-08-17 00:00:00

abstract：:Treatment advances and outcomes data have raised new concerns about how to optimize care for patients with HIV infection. This paper reviews evidence on 1) the relation between experience and type of training and patient outcomes, 2) the relation between the components of primary care and patient outcomes, and 3) prim...

journal_title：Annals of internal medicine

authors： Hecht FM,Wilson IB,Wu AW,Cook RL,Turner BJ

更新日期：1999-07-20 00:00:00

abstract：BACKGROUND:Visits to physicians for genital herpes simplex virus (HSV) infection continue to increase. Most patients with symptomatic infections have recurrences, but no studies of the long-term clinical course of genital herpes are available. OBJECTIVE:To determine whether the frequency of HSV recurrences decreases o...

journal_title：Annals of internal medicine

authors： Benedetti JK,Zeh J,Corey L

更新日期：1999-07-06 00:00:00

abstract：BACKGROUND:Hyperuricemia is associated with risk for cardiovascular disease and death. However, the role of uric acid independent of established risk factors is uncertain. OBJECTIVE:To examine the relation of serum uric acid level to incident coronary heart disease, death from cardiovascular disease, and death from al...

journal_title：Annals of internal medicine

authors： Culleton BF,Larson MG,Kannel WB,Levy D

更新日期：1999-07-06 00:00:00

abstract：:Bayesian inference is usually presented as a method for determining how scientific belief should be modified by data. Although Bayesian methodology has been one of the most active areas of statistical development in the past 20 years, medical researchers have been reluctant to embrace what they perceive as a subjectiv...

journal_title：Annals of internal medicine

authors： Goodman SN

更新日期：1999-06-15 00:00:00

abstract：BACKGROUND:Little evidence exists to support the theory that small-bore nasogastric tubes prevent gastroesophageal reflux and microaspiration in intubated patients. OBJECTIVE:To determine whether gastroesophageal reflux and microaspiration in intubated patients can be reduced by the use of a small-bore nasogastric tub...

journal_title：Annals of internal medicine

authors： Ferrer M,Bauer TT,Torres A,Hernández C,Piera C

更新日期：1999-06-15 00:00:00

abstract：:The term functional somatic syndrome has been applied to several related syndromes characterized more by symptoms, suffering, and disability than by consistently demonstrable tissue abnormality. These syndromes include multiple chemical sensitivity, the sick building syndrome, repetition stress injury, the side effect...

journal_title：Annals of internal medicine

authors： Barsky AJ,Borus JF

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The appropriate duration of therapy for catheter-associated Staphylococcus aureus bacteremia is controversial. Conventional practice dictates that all patients receive prolonged courses of intravenous antibiotics. Some clinicians recommend abbreviated therapeutic courses, but an alternate approach involves p...

journal_title：Annals of internal medicine

authors： Rosen AB,Fowler VG Jr,Corey GR,Downs SM,Biddle AK,Li J,Jollis JG

更新日期：1999-05-18 00:00:00

abstract：BACKGROUND:The appropriate roles for several diagnostic tests for coronary disease are uncertain. OBJECTIVE:To evaluate the cost-effectiveness of alternative approaches to diagnosis of coronary disease. DESIGN:Meta-analysis of the accuracy of alternative diagnostic tests plus decision analysis to assess the health ou...

journal_title：Annals of internal medicine

authors： Garber AM,Solomon NA

更新日期：1999-05-04 00:00:00

abstract：BACKGROUND:Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism. OBJECTIVE:To evaluate the risk for venous thromboembolism associated with the factor V Leiden mutation or with resistance to activated protein C in t...

journal_title：Annals of internal medicine

authors： Rodeghiero F,Tosetto A

更新日期：1999-04-20 00:00:00

abstract：:The autoimmune lymphoproliferative syndrome (ALPS) affords novel insights into the mechanisms that regulate lymphocyte homeostasis and underlie the development of autoimmunity. This syndrome arises early in childhood in persons who inherit mutations in genes that mediate apoptosis, or programmed cell death. The timely...

journal_title：Annals of internal medicine

authors： Straus SE,Sneller M,Lenardo MJ,Puck JM,Strober W

更新日期：1999-04-06 00:00:00

abstract：:Physicians are often asked to make prognostic assessments but often worry that their assessments will prove inaccurate. Prognostic systems were developed to enhance the accuracy of such assessments. This paper describes an approach for evaluating prognostic systems based on the accuracy (calibration and discrimination...

journal_title：Annals of internal medicine

authors： Justice AC,Covinsky KE,Berlin JA

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:Soon, half of all physicians may be married to other physicians (that is, in dual-doctor families). Little is known about how marriage to another physician affects physicians themselves. OBJECTIVE:To learn how physicians in dual-doctor families differ from other physicians in their professional and family l...

journal_title：Annals of internal medicine

authors： Sobecks NW,Justice AC,Hinze S,Chirayath HT,Lasek RJ,Chren MM,Aucott J,Juknialis B,Fortinsky R,Youngner S,Landefeld CS

更新日期：1999-02-16 00:00:00

abstract：:The hospital-based generalist physician is a recent organizational innovation in health care in the United States. Does the hospitalist model provide improved health care? The answer to this question lies in a rigorous evaluation of the hospitalist system in the clinical setting. This paper describes key outcomes that...

journal_title：Annals of internal medicine

authors： Showstack J,Katz PP,Weber E

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is a common cause of serious infection in patients infected with HIV. OBJECTIVES:To evaluate risk factors for and quantitative effect of S. aureus infection in HIV-infected patients, with special attention to nasal carriage. DESIGN:Prospective, multihospital cohort study. SETTING:Thr...

journal_title：Annals of internal medicine

authors： Nguyen MH,Kauffman CA,Goodman RP,Squier C,Arbeit RD,Singh N,Wagener MM,Yu VL

更新日期：1999-02-02 00:00:00

abstract：BACKGROUND:Several studies show an inverse association between self-reported physical activity and type 2 diabetes. It is not known whether physical activity or cardiorespiratory fitness is associated with the onset of objectively determined impaired fasting glucose and type 2 diabetes. OBJECTIVE:To determine whether ...

journal_title：Annals of internal medicine

authors： Wei M,Gibbons LW,Mitchell TL,Kampert JB,Lee CD,Blair SN

更新日期：1999-01-19 00:00:00

abstract：BACKGROUND:Medical students may be at high risk for occupational exposures to blood. OBJECTIVE:To measure the frequency of medical students' exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN:Revi...

journal_title：Annals of internal medicine

authors： Osborn EH,Papadakis MA,Gerberding JL

更新日期：1999-01-05 00:00:00

abstract：:This paper describes the role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism. Inability to compress the common femoral or popliteal vein is usually diagnostic of a first episode of deep venous thrombosis in symptomatic patients (positive predictive value of about ...

journal_title：Annals of internal medicine

authors： Kearon C,Ginsberg JS,Hirsh J

更新日期：1998-12-15 00:00:00

abstract：:Population screening for hemochromatosis done by using the transferrin saturation test has been advocated by experts to permit the initiation of therapeutic phlebotomy before the onset of clinical disease. The discovery of a gene associated with hemochromatosis has made DNA testing another option for screening and dia...

journal_title：Annals of internal medicine

authors： Cogswell ME,McDonnell SM,Khoury MJ,Franks AL,Burke W,Brittenham G

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Left bundle-branch block (BBB) is considered an important predictor of poor outcome in patients with acute myocardial infarction, but the consequences of right BBB are not well understood. OBJECTIVES:To 1) estimate the prevalence of left and right BBB in patients with myocardial infarction; 2) compare the c...

journal_title：Annals of internal medicine

authors： Go AS,Barron HV,Rundle AC,Ornato JP,Avins AL

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Exercise stress testing in patients with abdominal aortic aneurysms may cause enlargement or rupture of aneurysms. OBJECTIVE:To evaluate the safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms. DESIGN:Retrospective descriptive study. SETTING:Tertiary care center. PATIE...

journal_title：Annals of internal medicine

authors： Best PJ,Tajik AJ,Gibbons RJ,Pellikka PA

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood. OBJECTIVE:To evaluate the relation between folate intake and incidence of colon cancer. DESIGN:Prospective cohort study. SETT...

journal_title：Annals of internal medicine

authors： Giovannucci E,Stampfer MJ,Colditz GA,Hunter DJ,Fuchs C,Rosner BA,Speizer FE,Willett WC

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies. OBJECTIVE:To examine the baseline and time-dependent risk factors for ventilator-associated pneumonia and to determine the conditional probability and cumulative risk ov...

journal_title：Annals of internal medicine

authors： Cook DJ,Walter SD,Cook RJ,Griffith LE,Guyatt GH,Leasa D,Jaeschke RZ,Brun-Buisson C

更新日期：1998-09-15 00:00:00

abstract：:Many health care professionals have sustained an almost single-minded conviction that disparities in access to health care across socioeconomic groups are the key reason for the major discrepancies in health status between wealthy persons and poor persons. Others, however, have argued that a host of factors work to cr...

journal_title：Annals of internal medicine

authors： Andrulis DP

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Few recent data are available on risk factors for perioperative supraventricular arrhythmia (SVA) after noncardiac surgery or on the effect of SVA on clinical outcomes. OBJECTIVE:To determine the incidence, clinical correlates, and effect on length of stay of perioperative SVA in patients having major nonca...

journal_title：Annals of internal medicine

authors： Polanczyk CA,Goldman L,Marcantonio ER,Orav EJ,Lee TH

更新日期：1998-08-15 00:00:00

abstract：:Relapsing polychondritis, an uncommon, chronic, multisystem disorder characterized by recurrent episodes of inflammation of cartilaginous tissues, can be life-threatening, debilitating, and difficult to diagnose. This review is based on the authors' experience with 36 patients with relapsing polychondritis who were fo...

journal_title：Annals of internal medicine

authors： Trentham DE,Le CH

更新日期：1998-07-15 00:00:00

abstract：BACKGROUND:Physical activity has been related to enhanced bone mass and improved physical functioning and thus may reduce the risk for osteoporotic fracture. OBJECTIVE:To determine whether higher levels of physical activity are related to lower incidence of hip, wrist, and vertebral fractures. DESIGN:Prospective coho...

journal_title：Annals of internal medicine

authors： Gregg EW,Cauley JA,Seeley DG,Ensrud KE,Bauer DC

更新日期：1998-07-15 00:00:00

abstract：:When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subseque...

journal_title：Annals of internal medicine

authors： Langford CA,Klippel JH,Balow JE,James SP,Sneller MC

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:In AIDS, nodular skin disease can result from various causes. OBJECTIVE:To report a new manifestation of microsporidial infection presenting as nodular skin disease with underlying osteomyelitis. DESIGN:Case report. SETTING:Tertiary-care military medical center in Washington, D.C. PATIENT:A 36-year-old w...

journal_title：Annals of internal medicine

authors： Kester KE,Turiansky GW,McEvoy PL

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Vertebral fractures are a hallmark of postmenopausal osteoporosis and an important end point in trials of osteoporosis treatment, but the clinical significance of these fractures remains uncertain. OBJECTIVE:To determine the association of new vertebral fractures with back pain and back-related functional l...

journal_title：Annals of internal medicine

authors： Nevitt MC,Ettinger B,Black DM,Stone K,Jamal SA,Ensrud K,Segal M,Genant HK,Cummings SR

更新日期：1998-05-15 00:00:00

abstract：:During the past decade, medical therapy for AIDS has become more effective but also prohibitively expensive. A medical tragedy has been transformed into a financial crisis, and society has responded by establishing special programs and sources of funding for AIDS. These maneuvers parallel earlier approaches to HIV tes...

journal_title：Annals of internal medicine

authors： Casarett DJ,Lantos JD

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Castleman disease, an unusual condition of unknown cause consisting of a massive proliferation of lymphoid tissue, remains a clinicopathologic diagnosis. Three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castleman disease have been des...

journal_title：Annals of internal medicine

authors： Herrada J,Cabanillas F,Rice L,Manning J,Pugh W

更新日期：1998-04-15 00:00:00

abstract：:Clinicians can use data to improve daily clinical practice. This paper offers eight principles for using data to support improvement in busy clinical settings: 1) seek usefulness, not perfection, in the measurement; 2) use a balanced set of process, outcome, and cost measures; 3) keep measurement simple (think big, bu...

journal_title：Annals of internal medicine

authors： Nelson EC,Splaine ME,Batalden PB,Plume SK

更新日期：1998-03-15 00:00:00

abstract：PURPOSE:To review evidence about thyroxine suppressive therapy in patients with thyroid nodules, including the clinical importance and natural history of nodules and the effects and potential side effects of thyroxine therapy. DATA SOURCES:English-language articles published from 1986 to December 1996 were identified ...

journal_title：Annals of internal medicine

authors： Gharib H,Mazzaferri EL

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Screening women for Chlamydia trachomatis in family planning clinics is associated with a reduced incidence of chlamydial sequelae. However, the question of whom to screen to maintain efficient use of resources remains controversial. OBJECTIVE:To assess the cost-effectiveness of chlamydial screening done ac...

journal_title：Annals of internal medicine

authors： Howell MR,Quinn TC,Gaydos CA

更新日期：1998-02-15 00:00:00